Skin Rejuvenate TB 500 

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Composition:

• Sodium hyaluronate
• TB-500, Snap-8, Argireline, Copper Peptide (GhK-Cu), Palmitoyl Tripeptide-1 (Pal-Ghk)
• Retinol, Allantoin USP, N-Acetyl Glucosamine, Centella Asiatica Extract, Mannitol, Sodium Pyruvate,
• Fermented Lactobacillus, Glycerin, Aqua
• Vitamin B Complex (Biotin, Folic Acid, Cyanocobalamin, Pyridoxine HCL, Niacinamide)


Areas of Application:

• Face
• Eye area and under-eye
• Neck and décolletage
• Hands


Skin Types for Application:

• Dull and dry skin
• Pale and uneven skin tone
• Acne-prone skin
• Damaged skin with collagen loss
• Skin with wrinkles and fine lines
• Skin with enlarged pores


Application Protocol:

3 sessions with a 2-week interval.


Cleopatra Youth Elixir contains peptides, coenzymes, vitamins, minerals, probiotics, hyaluronic acid, and antioxidants.

• Hyaluronic acid with a molecular weight of less than 100 mg.
• Provides deep hydration due to its low molecular weight.
• Cleopatra Youth Elixir is the only mesotherapy product containing signal peptides, neuropeptides, and “carrier” peptides.


Signal Peptides: TB500, Matrixyl, Pal-Ghk
These stimulate skin fibroblasts, increasing collagen and elastin production.

Neuropeptides: Snap-8, Argireline
These specifically inhibit neurosecretion, preventing the formation of wrinkles.


Regenerative Peptides TB500 (Thymosin B4):
Made up of 43 amino acids.
• TB500 is a naturally occurring peptide with a low molecular weight that plays a key role in the regeneration and repair of damaged cells and tissues.
• TB500 protects cells and tissues from damage, reducing apoptosis, inflammation, and microbial growth.
• TB500 promotes stem cell migration, stimulates the formation of new blood vessels, and helps repair tissue.
• TB500 reduces the number of myofibroblasts in wounds, thus preventing scar formation and reducing fibrosis.


Lipopeptide:
Easily penetrates the skin, helping to reduce fine lines and wrinkles, improving the overall health and appearance of the skin.


Copper Peptide (GhK-Cu):
Stimulates the production of collagen, elastin, and glycosaminoglycans (such as hyaluronic acid), offering powerful antioxidant properties. This leads to improved skin healing, firmness, and smoothness, resulting in the reduction of fine lines and wrinkles.


Palmitoyl Tripeptide-1 (Pal-Ghk):
Helps improve skin smoothness and firmness.


L-Arginine:
Reduces the appearance of fine lines and wrinkles, helping to keep the skin firm, plump, and smooth.


Mannitol and Sodium Pyruvate:
Both are antioxidants.

Centella Asiatica:
Supports skin regeneration.

Fermented Lactobacillus:
Probiotic.

Retinol:
Evens out skin tone.

Allantoin:
Anti-inflammatory, soothing, moisturizing, and keratolytic.

Glycerin:
Antibacterial and moisturizing.

N-Acetyl Glucosamine:
Anti-aging and skin-brightening properties.

Vitamin B Complex:
Biotin, Folic Acid, Cyanocobalamin, Pyridoxine HCL, Niacinamide.


Biological Activity and Mechanism of Action:

  1. Reduces inflammation:
    Cytokines and chemokines reduce inflammation by inhibiting NF-kB activation.
  2. Provides chemotaxis for endothelial cells and keratinocytes (attracting chemicals to pathogens):
    Regulates F- and G-actin.
  3. Reduces chemical and/or oxygen deficiency:
    Protects cells from cytotoxicity by reducing intracellular ROS and has antioxidant effects.
  4. Stimulates angiogenesis:
    Increases VEGF synthesis, enhancing the VEGF/AKT signaling pathway.
  5. Promotes stem cell migration and differentiation:
    Helps regenerate skin, heart, and nerve tissues, increasing cellular migration.
  6. Reduces apoptosis (cell death):
    Increases the expression of anti-apoptotic enzymes, regulating the Bax/Bcl(2) ratio.
  7. Accelerates collagen synthesis and regulates laminin-5 secretion:
    Reduces ROS and activates the laminin-5 gene.
  8. Reduces scar formation:
    Speeds up scar reduction, allowing for better collagen fibril organization and preventing myofibroblast infiltration.